2024

Kim K, Oblak E, Manella K, Sulzer J. Simulated operant reflex conditioning environment reveals effects of feedback parameters. PLoS One. 2024 Mar 21;19(3):e0300338. doi: 10.1371/journal.pone.0300338. PMID: 38512998; PMCID: PMC10956789.

2023

Wolpaw JR, Thompson AK. Enhancing neurorehabilitation by targeting beneficial plasticity. Front Rehabil Sci. 2023 Jun 29;4:1198679. doi: 10.3389/fresc.2023.1198679. PMID: 37456795; PMCID: PMC10338914.

McKinnon ML, Hill NJ, Carp JS, Dellenbach B, Thompson AK. Methods for automated delineation and assessment of EMG responses evoked by peripheral nerve stimulation in diagnostic and closed-loop therapeutic applications. J Neural Eng. 2023 Jul 21;20(4). doi: 10.1088/1741-2552/ace6fb. PMID: 37437593.

Kim K, Akbas T, Lee R, Manella K, Sulzer J. Self-modulation of rectus femoris reflex excitability in humans. Sci Rep. 2023 May 19;13(1):8134. doi: 10.1038/s41598-023-34709-4. PMID: 37208394; PMCID: PMC10198967.

Johnson KA, Petrie MA, Shields RK. Biomarkers for rapid H-reflex operant conditioning among females. J Neurophysiol. 2023 Mar 1;129(3):685-699. doi: 10.1152/jn.00188.2022. Epub 2023 Feb 15. PMID: 36791051; PMCID: PMC10010925

Phipps, AM, Thompson, AK. Operant up-conditioning of the soleus cutaneous reflex to non-noxious stimuli in a person with chronic incomplete spinal cord injury. Clinical Neurophysiology. 2023 Nov 15. https://doi.org/10.1016/j.clinph.2023.11.004 

2022

Thompson AK, Gill CR, Feng W, and Segal RL. Operant down-conditioning of the soleus H-reflex in people after stroke. Front Rehabilit Sci 3: 859724, 2022.

Hill NJ, Gupta D, Eftekhar A, Brangaccio JA, Norton JJS, McLeod M, Fake T, Wolpaw JR, Thompson AK. Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders. J Vis Exp. 2022 Aug 25;(186). doi: 10.3791/63736.

2021

Thompson AK, Wolpaw JR. H-reflex conditioning during locomotion in people with spinal cord injury. J Physiol. 2021;599:2453-69. doi: 10.1113/JP278173. PMID: 31215646.

2020

Thompson, AK, Sinkjaer T. (2020) Can operant conditioning of EMG evoked responses help to target corticospinal plasticity for improving motor function in people with multiple sclerosis? Front Neurol. doi:10.3389/fneur.2020.00552

2019

Mrachacz-Kersting N, Kersting UG, de Brito Silva P, Makihara Y, Arendt-Nielsen L, Sinkjaer T, Thompson AK. (2019). Acquisition of a simple motor skill: task-dependent adaptation and long-term changes in the human soleus stretch reflex. J Neurophysiol. 122(1):4350446. doi:10.11.52/jn.00211.2019.

Thompson, A. K., Fiorenza, G., Smyth, L., Favale, B., Brangaccio, J., & Sniffen, J. (2019). Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury. Journal of Neurophysiology, 121(3), 853-866. doi:10.1152/jn.00557.2018

2018

Thompson, A. K., Cote, R. H., Sniffen, J. M., & Brangaccio, J. A. (2018). Operant conditioning of the tibialis anterior motor evoked potential in people with and without chronic incomplete spinal cord injury. Journal of Neurophysiology, 120(6), 2745-2760. doi:10.1152/jn.00362.2018

Thompson, A. K., Favale, B. M., Velez, J., & Falivena, P. (2018). Operant Up-Conditioning of the Tibialis Anterior Motor-Evoked Potential in Multiple Sclerosis: Feasibility Case Studies. Neural Plasticity, 2018, 1-10. doi:10.1155/2018/4725393

2016

Thompson, A. K., Cote, R. H., & Thompson, C. R. (2016). Operant Conditioning of the Tibialis Anterior Motor Evoked Potential to Transcranial Magnetic Stimulation. Converging Clinical and Engineering Research on Neurorehabilitation II Biosystems & Biorobotics, 29-32. doi:10.1007/978-3-319-46669-9_6

Thompson, A. K., Pudlik, S. D., & Thompson, C. R. (2016). Effects of H-Reflex Operant Conditioning in Humans. Converging Clinical and Engineering Research on Neurorehabilitation II Biosystems & Biorobotics, 53-57. doi:10.1007/978-3-319-46669-9_10

2015

Thompson, A. K., & Wolpaw, J. R. (2015). Targeted neuroplasticity for rehabilitation. Sensorimotor Rehabilitation – At the Crossroads of Basic and Clinical Sciences Progress in Brain Research, 157-172. doi:10.1016/bs.pbr.2015.02.002

2014

Makihara, Y., Segal, R. L., Wolpaw, J. R., & Thompson, A. K. (2014). Operant conditioning of the soleus H-reflex does not induce long-term changes in the gastrocnemius H-reflexes and does not disturb normal locomotion in humans. Journal of Neurophysiology, 112(6), 1439-1446. doi:10.1152/jn.00225.2014

Thompson, A. K., & Wolpaw, J. R. (2014). Operant conditioning of spinal reflexes: From basic science to clinical therapy. Frontiers in Integrative Neuroscience, 8. doi:10.3389/fnint.2014.00025

Thompson, A. K., & Wolpaw, J. R. (2014). Restoring Walking after Spinal Cord Injury. The Neuroscientist, 21(2), 203-215. doi:10.1177/1073858414527541

Thompson, A. K., & Wolpaw, J. R. (2014). The Simplest Motor Skill: mechanisms and applications of reflex operant conditioning. Exercise and Sport Sciences Reviews, 42(2), 82-90. doi:10.1249/jes.0000000000000010

2013

Manella, K. J., Roach, K. E., & Field-Fote, E. C. (2013). Operant conditioning to increase ankle control or decrease reflex excitability improves reflex modulation and walking function in chronic spinal cord injury. Journal of Neurophysiology, 109(11), 2666-2679. doi:10.1152/jn.01039.2011

Thompson AK, Pomerantz F, Wolpaw JR. Operant conditioning of a spinal reflex can improve locomotion after spinal cord injury in humans. J Neurosci. 33:2365-2375, 2013. PMCID: 3579496.

2012

Thompson, A. K., Chen, X. Y., & Wolpaw, J. R. (2012). Soleus H-reflex operant conditioning changes the H-reflex recruitment curve. Muscle & Nerve, 47(4), 539-544. doi:10.1002/mus.23620

2011

Chen, Y., Chen, L., Wang, Y., Wolpaw, J. R., & Chen, X. Y. (2011). Operant Conditioning of Rat Soleus H-Reflex Oppositely Affects Another H-Reflex and Changes Locomotor Kinematics. Journal of Neuroscience, 31(31), 11370-11375. doi:10.1523/jneurosci.1526-11.2011

Makihara, Y., Segal, R. L., Wolpaw, J. R., & Thompson, A. K. (2011). H-reflex modulation in the human medial and lateral gastrocnemii during standing and walking. Muscle & Nerve, 45(1), 116-125. doi:10.1002/mus.22265

Thompson, A. K., Lapallo, B., Duffield, M., Abel, B. M., & Pomerantz, F. (2011). Repetitive common peroneal nerve stimulation increases ankle dorsiflexor motor evoked potentials in incomplete spinal cord lesions. Experimental Brain Research, 210(1), 143-152. doi:10.1007/s00221-011-2607-1

2010

Chen, X. Y., Chen, Y., Wang, Y., Thompson, A., Carp, J. S., Segal, R. L., & Wolpaw, J. R. (2010). Reflex conditioning: A new strategy for improving motor function after spinal cord injury. Annals of the New York Academy of Sciences, 1198. doi:10.1111/j.1749-6632.2010.05565.x

2009

Thompson, A. K., Chen, X. Y., & Wolpaw, J. R. (2009). Acquisition of a Simple Motor Skill: Task-Dependent Adaptation Plus Long-Term Change in the Human Soleus H-Reflex. Journal of Neuroscience, 29(18), 5784-5792. doi:10.1523/jneurosci.4326-08.2009

2006

Carp, J. S., Tennissen, A. M., Chen, X. Y., & Wolpaw, J. R. (2006). H-Reflex Operant Conditioning in Mice. Journal of Neurophysiology, 96(4), 1718-1727. doi:10.1152/jn.00470.2006

Chen, Y., Chen, X. Y., Jakeman, L. B., Chen, L., Stokes, B. T., & Wolpaw, J. R. (2006). Operant Conditioning of H-Reflex Can Correct a Locomotor Abnormality after Spinal Cord Injury in Rats. Journal of Neuroscience, 26(48), 12537-12543. doi:10.1523/jneurosci.2198-06.2006

Chen, X. Y., Chen, L., Chen, Y., & Wolpaw, J. R. (2006). Operant Conditioning of Reciprocal Inhibition in Rat Soleus Muscle. Journal of Neurophysiology, 96(4), 2144-2150. doi:10.1152/jn.00253.2006

Thompson, A. K., Stein, R. B., Chen, X. Y., & Wolpaw, J. R. (2006). Modulation in spinal circuits and corticospinal connections following nerve stimulation and operant conditioning. 2006 International Conference of the IEEE Engineering in Medicine and Biology Society. doi:10.1109/iembs.2006.259544

2002

Chen, X. Y., Carp, J. S., Chen, L., & Wolpaw, J. R. (2002). Corticospinal tract transection prevents operantly conditioned H-reflex increase in rats. Experimental Brain Research, 144(1), 88-94. doi:10.1007/s00221-002-1026-8

2001

Carp, J., Chen, X., Sheikh, H., & Wolpaw, J. (2001). Motor unit properties after operant conditioning of rat H-reflex. Experimental Brain Research, 140(3), 382-386. doi:10.1007/s002210100830

Carp, J. S., Chen, X., Sheikh, H., & Wolpaw, J. R. (2001). Operant conditioning of rat H-reflex affects motoneuron axonal conduction velocity. Experimental Brain Research, 136(2), 269-273. doi:10.1007/s002210000608

Wolpaw, J. R., & Chen, X. Y. (2001). Operant conditioning of rat H-reflex: Effects on mean latency and duration. Experimental Brain Research, 136(2), 274-279. doi:10.1007/s002210000609

1999

Chen, X. Y., Wolpaw, J. R., Jakeman, L. B., & Stokes, B. T. (1999). Operant Conditioning of H-Reflex Increase in Spinal Cord–Injured Rats. Journal of Neurotrauma, 16(2), 175-186. doi:10.1089/neu.1999.16.175

1997

Segal, R. L. (1997). Plasticity in the Central Nervous System: Operant Conditioning of the Spinal Stretch Reflex. Topics in Stroke Rehabilitation, 3(4), 76-87. doi:10.1080/10749357.1997.11754130

1996

Chen, X., & Wolpaw, J. (1996). Reversal of H-reflex operant conditioning in the rat. Experimental Brain Research, 112(1). doi:10.1007/bf00227178

Chen, X. Y., Wolpaw, J. R., Jakeman, L. B., & Stokes, B. T. (1996). Operant Conditioning of H-Reflex in Spinal Cord-Injured Rats. Journal of Neurotrauma, 13(12), 755-766. doi:10.1089/neu.1996.13.755

Feng-Chen, K. C., & Wolpaw, J. R. (1996). Operant conditioning of H-reflex changes synaptic terminals on primate motoneurons. Proceedings of the National Academy of Sciences, 93(17), 9206-9211. doi:10.1073/pnas.93.17.9206

1995

Chen, X. Y., & Wolpaw, J. R. (1995). Operant conditioning of H-reflex in freely moving rats. Journal of Neurophysiology, 73(1), 411-415. doi:10.1152/jn.1995.73.1.411

1994

Segal, R. L., & Wolf, S. L. (1994). Operant Conditioning of Spinal Stretch Reflexes in Patients with Spinal Cord Injuries. Experimental Neurology, 130(2), 202-213. doi:10.1006/exnr.1994.1199

Wolpaw, J. R., Maniccia, D. M., & Elia, T. (1994). Operant conditioning of primate H-reflex: Phases of development. Neuroscience Letters, 170(2), 203-207. doi:10.1016/0304-3940(94)90319-0

1993

Wolpaw, J., Herchenroder, P., & Carp, J. (1993). Operant conditioning of the primate H-reflex: Factors affecting the magnitude of change. Experimental Brain Research, 97(1). doi:10.1007/bf00228815

1990

Wolpaw, J. R., & Herchenroder, P. A. (1990). Operant conditioning of H-reflex in freely moving monkeys. Journal of Neuroscience Methods, 31(2), 145-152. doi:10.1016/0165-0270(90)90159-d

1989

Evatt, M., Wolf, S., & Segal, R. (1989). Modification of human spinal stretch reflexes: Preliminary studies. Neuroscience Letters, 105(3), 350-355. doi:10.1016/0304-3940(89)90646-0

Wolpaw, J. R., & Lee, C. L. (1989). Memory traces in primate spinal cord produced by operant conditioning of H-reflex. Journal of Neurophysiology, 61(3), 563-572. doi:10.1152/jn.1989.61.3.563

Wolpaw, J., Lee, C., & Calaitges, J. (1989). Operant conditioning of primate triceps surae H-reflex produces reflex asymmetry. Experimental Brain Research, 75(1). doi:10.1007/bf00248527

1988

Wolpaw, J. R., & Dowman, R. (1988). Operant conditioning of primate spinal reflexes: Effect on cortical SEPs. Electroencephalography and Clinical Neurophysiology, 69(4), 398-401. doi:10.1016/0013-4694(88)90012-0

1987

Wolpaw, J. R. (1987). Operant conditioning of primate spinal reflexes: The H-reflex. Journal of Neurophysiology, 57(2), 443-459. doi:10.1152/jn.1987.57.2.443